Protein–protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches

AG Ngounou Wetie, I Sokolowska, AG Woods… - Cellular and molecular …, 2014 - Springer
Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

Maternal SSRI exposure increases the risk of autistic offspring: a meta-analysis and systematic review

S Andalib, MR Emamhadi… - European …, 2017 - cambridge.org
Background: Selective serotonin reuptake inhibitors (SSRIs) are the most common
antidepressants used to preclude maternal pregnancy depression. There is a growing body …

A pilot proteomic analysis of salivary biomarkers in autism spectrum disorder

AG Ngounou Wetie, KL Wormwood, S Russell… - Autism …, 2015 - Wiley Online Library
Autism spectrum disorder (ASD) prevalence is increasing, with current estimates at 1/68–
1/50 individuals diagnosed with an ASD. Diagnosis is based on behavioral assessments …

Stress and salivary glands

B Keremi, A Beck, T Karoly Fabian… - Current …, 2017 - ingentaconnect.com
Salivary glands produce a bicarbonate-rich fluid containing digestive and protective proteins
and other components to be delivered into the gastrointestinal tract. Its function is under strict …

Identification of posttranslational modifications (PTMs) of proteins by mass spectrometry

R Aslebagh, KL Wormwood… - Advancements of mass …, 2019 - Springer
There are only 30,000 human genes, which, according to the central dogma from biology, it
means that there should be 30,000 mRNA and 30,000 proteins. However, there are at least …

Synthesis and application of a “plastic antibody” in electrochemical microfluidic platform for oxytocin determination

PS Sharma, Z Iskierko, K Noworyta, M Cieplak… - Biosensors and …, 2018 - Elsevier
By means of molecular imprinting of a conducting polymer, molecular cavities selective for
oxytocin nonapeptide, an autism biomarker, were designed. Embedding of the oxytocin …

Cancer secretomes and their place in supplementing other hallmarks of cancer

S Patel, AGN Wetie, CC Darie, BD Clarkson - Advancements of mass …, 2014 - Springer
The secretome includes all macromolecules secreted by cells, in particular conditions at
defined times, allowing cell–cell communication. Cancer cell secretomes that are altered …

Emerging proteomic approaches to identify the underlying pathophysiology of neurodevelopmental and neurodegenerative disorders

N Murtaza, J Uy, KK Singh - Molecular Autism, 2020 - Springer
Proteomics is the large-scale study of the total protein content and their overall function
within a cell through multiple facets of research. Advancements in proteomic methods have …

Salivary proteomics and biomarkers in neurology and psychiatry

KL Wormwood, R Aslebagh… - PROTEOMICS …, 2015 - Wiley Online Library
Biomarkers are greatly needed in the fields of neurology and psychiatry, to provide objective
and earlier diagnoses of CNS conditions. Proteomics and other omics MS‐based …

A pilot proteomic study of protein markers in autism spectrum disorder

AG Ngounou Wetie, K Wormwood, J Thome… - …, 2014 - Wiley Online Library
Autism spectrum disorder (ASD) diagnosis is increasing, with 1/88 children believed to be
affected by the disorder, with a most recent survey suggesting numbers as high as 1/50 …