[HTML][HTML] Prophylactic HPV vaccines in patients with HPV-associated diseases and cancer

M Reuschenbach, J Doorbar, M Del Pino, EA Joura… - Vaccine, 2023 - Elsevier
Individuals with human papillomavirus (HPV)-related disease remain at risk for subsequent
HPV infection and related disease after treatment of specific lesions. Prophylactic HPV …

What are the essential determinants of human papillomavirus carcinogenesis?

K Munger, EA White - Mbio, 2024 - journals.asm.org
Human papillomavirus (HPV) infection is the leading viral cause of cancer. Over the past
several decades, research on HPVs has provided remarkable insight into human cell …

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

J Hatterschide, P Castagnino, HW Kim, SM Sperry… - Elife, 2022 - elifesciences.org
Persistent human papillomavirus (HPV) infection of stratified squamous epithelial cells
causes nearly 5% of cancer cases worldwide. HPV-positive oropharyngeal cancers harbor …

Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer

MC Bedard, T Chihanga, A Carlile, R Jackson… - Nature …, 2023 - nature.com
Persistent HPV16 infection is a major cause of the global cancer burden. The viral life cycle
is dependent on the differentiation program of stratified squamous epithelium, but the …

HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation

W Yin, N Egawa, K Zheng, H Griffin, P Tian… - PLoS …, 2023 - journals.plos.org
Human papillomaviruses (HPV) cause persistent infections by modulating epithelial
homeostasis in cells of the infected basal layer. Using FUCCI and cell-cell competition …

[HTML][HTML] The human Papillomavirus twilight zone–Latency, immune control and subclinical infection

J Doorbar - Tumour Virus Research, 2023 - Elsevier
The incorporation of HPV DNA testing into cervical screening programs has shown that
many HPV-positive women are cytologically normal, with HPV-positivity fluctuating …

[HTML][HTML] Elimination of reserve cells for prevention of HPV-associated cervical cancer

O Reich, S Regauer - Virus Research, 2023 - Elsevier
Human papilloma viruses (HPV), that are causative for most squamous cell cervical cancers
(SCC), have a simple structure with only a few genes (six early and two late genes). Two of …

The human papillomavirus late life cycle and links to keratinocyte differentiation

A Kirk, SV Graham - Journal of Medical Virology, 2024 - Wiley Online Library
Regulation of human papillomavirus (HPV) gene expression is tightly linked to differentiation
of the keratinocytes the virus infects. HPV late gene expression is confined to the cells in the …

It takes two to tango: a review of oncogenic virus and host microbiome associated Inflammation in head and neck cancer

MG McKeon, JN Gallant, YJ Kim, SR Das - Cancers, 2022 - mdpi.com
Simple Summary Certain viruses, specifically, human papillomavirus (HPV) and Epstein–
Barr virus (EBV), have been linked with the development of head and neck cancer. In this …

Non-human primate papillomavirus E6-mediated p53 degradation reveals ancient evolutionary adaptation of carcinogenic phenotype to host niche

T Long, RD Burk, PKS Chan, Z Chen - PLoS pathogens, 2022 - journals.plos.org
Non-human primates (NHPs) are infected with papillomaviruses (PVs) closely related to
their human counterparts, but there are few studies on the carcinogenicity of NHP-PVs …