Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …

The mammalian blood system, containing more than 10 distinct mature cell types, stands on
one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess …

In the human hematopoietic system, aging is associated with decreased bone marrow
cellularity, decreased adaptive immune system function, and increased incidence of anemia …

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …

▪ Abstract Multipotent stem cells are clonal cells that self-renew as well as differentiate to
regenerate adult tissues. Whereas stem cells and their fates are known by unique genetic …

The recent prospective isolation of a wide variety of somatically derived stem cells has
affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by …

Mouse hematopoiesis is initiated by long-term hematopoietic stem cells (HSC) that
differentiate into a series of multipotent progenitors that exhibit progressively diminished self …

Genome editing with targeted nucleases and DNA donor templates homologous to the
break site has proven challenging in human hematopoietic stem and progenitor cells …