The bone marrow in the skull is important for shaping immune responses in the brain and
meninges, but its molecular makeup among bones and relevance in human diseases …

This paper provides an overview of the role of neuroinflammation in Alzheimer's disease
and other neurodegenerative diseases, highlighting the potential of anti-inflammatory …

Triggering receptor expressed on myeloid cells 2 (TREM2) plays an essential role in
microglia activation and is being investigated as a potential therapeutic target for modulation …

Purpose: Current therapy strategies still provide only limited success in the treatment of
glioblastoma, the most frequent primary brain tumor in adults. In addition to the …

Abstract Purpose 2-Fluorodeoxyglucose-PET (FDG-PET) is a powerful tool to study glucose
metabolism in mammalian brains, but cellular sources of glucose uptake and metabolic …

Background: The translocator protein (TSPO) has been proven to have great potential as a
target for the positron emission tomography (PET) imaging of glioblastoma. However, there …

Background Non-auditory symptoms can be a prominent feature in patients with sporadic
vestibular schwannoma (VS), but the cause of these symptoms is unknown. Inflammation is …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial
activity and sequence variants are major risk factors for late onset Alzheimer's disease …

Tau-PET receives growing interest as an imaging biomarker for the 4-repeat tauopathy
progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to …

Background Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology
but the impact of the regional interplay of microglia cells in the brain is poorly understood …