RNA in extracellular vesicles

KM Kim, K Abdelmohsen, M Mustapic… - Wiley …, 2017 - Wiley Online Library
Cells release a range of membrane‐enclosed extracellular vesicles (EVs) into the
environment. Among them, exosomes and microvesicles (collectively measuring 40–1000 …

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

F Pistollato, S Sumalla Cano, I Elio… - Nutrition …, 2016 - academic.oup.com
It has been hypothesized that alterations in the composition of the gut microbiota might be
associated with the onset of certain human pathologies, such as Alzheimer disease, a …

Human breast milk: from food to active immune response with disease protection in infants and mothers

GAG Lokossou, L Kouakanou, A Schumacher… - Frontiers in …, 2022 - frontiersin.org
Breastfeeding is associated with long-term wellbeing including low risks of infectious
diseases and non-communicable diseases such as asthma, cancer, autoimmune diseases …

Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood

L Cheng, RA Sharples, BJ Scicluna… - Journal of extracellular …, 2014 - Taylor & Francis
Introduction microRNA (miRNA) are small non-coding RNA species that are transcriptionally
processed in the host cell and released extracellularly into the bloodstream. Normally …

Plasma exosomal miRNAs in persons with and without Alzheimer disease: altered expression and prospects for biomarkers

G Lugli, AM Cohen, DA Bennett, RC Shah, CJ Fields… - PloS one, 2015 - journals.plos.org
To assess the value of exosomal miRNAs as biomarkers for Alzheimer disease (AD), the
expression of microRNAs was measured in a plasma fraction enriched in exosomes by …

Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment

L Cheng, JD Doecke, RA Sharples, VL Villemagne… - Molecular …, 2015 - nature.com
There is no consensus for a blood-based test for the early diagnosis of Alzheimer's disease
(AD). Expression profiling of small non-coding RNA's, microRNA (miRNA), has revealed …

Methodological challenges in utilizing mi RNA s as circulating biomarkers

L Moldovan, KE Batte, J Trgovcich… - Journal of cellular …, 2014 - Wiley Online Library
Micro RNA s (mi RNA s) have emerged as important regulators in the post‐transcriptional
control of gene expression. The discovery of their presence not only in tissues but also in …

[HTML][HTML] Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine

L Cheng, X Sun, BJ Scicluna, BM Coleman, AF Hill - Kidney international, 2014 - Elsevier
Micro RNAs (miRNAs) have been shown to circulate in biological fluids and are enclosed in
vesicles such as exosomes; they are present in urine and represent a noninvasive …

Blood-based biomarkers for Alzheimer's disease diagnosis and progression: an overview

A Varesi, A Carrara, VG Pires, V Floris, E Pierella… - Cells, 2022 - mdpi.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …

Circulating exosomal miRNA as diagnostic biomarkers of neurodegenerative diseases

L Wang, L Zhang - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases (NDDs) are a group of diseases caused by chronic and
progressive degeneration of neural tissue. The main pathological manifestations are …