Multicellular PID control for robust regulation of biological processes

V Martinelli, D Fiore, D Salzano… - Journal of the Royal …, 2025 - royalsocietypublishing.org
This article presents the first implementation of a proportional-integral-derivative (PID)
biomolecular controller within a consortium of different cell populations, aimed at robust …

Multicellular proportional-integral-derivative control for robust regulation of biological processes

V Martinelli, D Fiore, D Salzano, M di Bernardo - bioRxiv, 2024 - biorxiv.org
This paper presents the first implementation of a Proportional-Integral-Derivative (PID)
biomolecular controller within a consortium of different cell populations, aimed at robust …

In-vivo distributed multicellular control of gene expression in microbial consortia

D Salzano, B Shannon, C Grierson, L Marucci… - bioRxiv, 2023 - biorxiv.org
This paper presents an innovative approach in synthetic biology, focusing on the
engineering of biomolecular feedback control systems within microbial consortia to achieve …

Biochemical implementation of acceleration sensing and PIDA control

E Alexis, S Espinel-Rios, IG Kevrekidis, JL Avalos - bioRxiv, 2024 - biorxiv.org
Designing dependable, self-regulated biochemical systems has long posed a challenge in
the field of Synthetic Biology. Here, we propose a realization of a Proportional-Integral …

AC-BioSD: A biomolecular signal differentiator module with enhanced performance (extended version)

E Alexis, JL Avalos, L Cardelli, A Papachristodoulou - bioRxiv, 2024 - biorxiv.org
Temporal gradient estimation is a pervasive phenomenon in natural biological systems and
holds great promise for synthetic counterparts with broad-reaching applications. Here, we …

[PDF][PDF] Hybrid quorum sensing and machine learning systems for adaptive synthetic biology: Toward autonomous gene regulation and precision therapies

DA Tuan, PVN Uyen, J Masak - 2024 - preprints.org
Quorum Sensing (QS) and Machine Learning (ML) hybrid systems represent a
groundbreaking innovation in synthetic biology, offering unprecedented control and …

AC-BioSD: A biomolecular signal differentiator module with enhanced performance

E Alexis, JL Avalos, L Cardelli… - IEEE Control Systems …, 2024 - ieeexplore.ieee.org
Temporal gradient estimation is a pervasive phenomenon in natural biological systems and
holds great promise for synthetic counterparts with broad-reaching applications. Here, we …

Feedback control of plant-soil autotoxicity via pulse-width modulation

T Rino, F Giannino, D Fiore - 2024 European Control …, 2024 - ieeexplore.ieee.org
Plant-soil negative feedback (PSNF) is the rise in soil of negative conditions for plant
performance induced by the plants themselves, limiting the full potential yield and thus …

Hybrid Platform for Swarm Robotics: Experiments and High-Dimensional Continuification Control

GC Maffettone, L Liguori, E Palermo… - arXiv preprint arXiv …, 2023 - arxiv.org
A significant challenge in control theory and technology is to devise agile and less resource-
intensive experiments for evaluating the performance and feasibility of control algorithms for …

In silico analysis of metabolic burden effects on a multicellular integral controller

G Campanile, V Martinelli, D Salzano, D Fiore… - bioRxiv, 2024 - biorxiv.org
Metabolic burden is a critical limiting factor in the design of synthetic circuits, affecting both
their reliability and performance. To mitigate its effects, distributing control functions across …