Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

The concept of antimicrobial peptides (AMPs) as potent pharmaceuticals is firmly
established in the literature, and most research articles on this topic conclude by stating that …

Persister cells (PCs) are a subset of dormant, phenotypic variants of regular bacteria, highly
tolerant to antibiotics. Generation of PCs in vivo may account for the recalcitrance of most …

Healthy human skin sustains an effective immune defense mechanism, formed by a complex
physical and chemical epidermal barrier that coordinates with different cellular components …

Human β-defensins (hBDs) stimulate degranulation in rat peritoneal mast cells in vitro and
cause increased vascular permeability in rats in vivo. In this study, we sought to determine …

Genomic sequencing, bioinformatics, and initial speciation (eg, relative abundance) of the
commensal microbiome have revolutionized the way we think about the “human” body in …

Staphylococcus aureus is a microorganism capable of causing numerous diseases of the
human skin. The incidence of S. aureus skin infections reflects the conflict between the host …

This review article presents important and recent progress in the manufacture and
application of antimicrobial macromolecules. Microbial infections continue to endanger …

The pervasiveness of bacterial resistance to conventional antibiotics, particularly those
associated with staphylococcal infections, has become a global epidemic. However …

Cationic and amphiphilic peptides are widely distributed in eukaryotic organisms and
constitute a first line of host defense against invading pathogens. Some of these host …