Immunosuppressive mechanisms of regulatory B cells

D Catalán, MA Mansilla, A Ferrier, L Soto… - Frontiers in …, 2021 - frontiersin.org
Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

Cells of the immune system in cardiac remodeling: main players in resolution of inflammation and repair after myocardial infarction

I Kologrivova, M Shtatolkina, T Suslova… - Frontiers in …, 2021 - frontiersin.org
The burden of heart failure (HF), developing after myocardial infarction MI, still represents a
major issue in clinical practice. Failure of appropriate resolution of inflammation during post …

A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair

K Sun, Y Li, J Jin - Signal transduction and targeted therapy, 2021 - nature.com
The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Management of inflammation in cardiovascular diseases

SK Goswami, P Ranjan, RK Dutta, SK Verma - Pharmacological research, 2021 - Elsevier
Cardiovascular disease is the leading cause of morbidity and mortality world-wide. Recently,
the role of inflammation in the progression of diseases has significantly attracted …

Immune and inflammatory networks in myocardial infarction: current research and its potential implications for the clinic

A Anzai, S Ko, K Fukuda - International journal of molecular sciences, 2022 - mdpi.com
Despite recent scientific and technological advances, myocardial infarction (MI) still
represents a major global health problem, leading to high morbidity and mortality worldwide …

Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies

F Porsch, Z Mallat, CJ Binder - Cardiovascular research, 2021 - academic.oup.com
Immune mechanisms are critically involved in the pathogenesis of atherosclerosis and its
clinical manifestations. Associations of specific antibody levels and defined B-cell subsets …

The why and how of adaptive immune responses in ischemic cardiovascular disease

Z Mallat, CJ Binder - Nature cardiovascular research, 2022 - nature.com
Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide.
Most therapeutic approaches target traditional risk factors but ignore the fundamental role of …

Inflammation in myocardial ischemia/reperfusion injury: underlying mechanisms and therapeutic potential

J Francisco, DP Del Re - Antioxidants, 2023 - mdpi.com
Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism

M Heinrichs, DED Ashour, J Siegel… - Cardiovascular …, 2021 - academic.oup.com
Aims Recent studies have revealed that B cells and antibodies can influence inflammation
and remodelling following a myocardial infarction (MI) and culminating in heart failure—but …

Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction

JC Snider, LA Riley, NT Mallory, MR Bersi… - Circulation, 2021 - Am Heart Assoc
Background: Myocardial infarction (MI) induces an intense injury response that ultimately
generates a collagen-dominated scar. Although required to prevent ventricular rupture, the …