Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining
attention for the treatment of different cancer types, but also to contrast neurodegenerative …

Parkinson's disease (PD) is a progressive neurodegenerative condition that primarily affects
motor function and is caused by a gradual decline of dopaminergic neurons in the brain's …

Sirtuins (SIRTs) are classified as class III histone deacetylases (HDACs), a family of
enzymes that catalyze the removal of acetyl groups from the ε-N-acetyl lysine residues of …

Macrophage-mediated inflammation plays essential roles in multiple-organ injury.
Sinensetin (SNS) at least exhibits anti-inflammation, antioxidant, and antitumor properties …

Human aging is associated with increased rates of many cardiac diseases and tissue
remodeling. However, disentangling the mechanisms that underlie normal heart aging from …

Background and purpose Our previous research discovered that cinnamamide derivatives
are a new type of potential cardioprotective agents myocardial ischemia-reperfusion (MIR) …

Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+)-dependent
class III histone deacetylases, which come into play in the regulation of epigenetic …

Cyclosporin A, an immunosuppressive agent, is extensively utilized for the prevention of
transplant rejection and treat autoimmune disease in the clinic, despite its association with a …

Background The accumulation of senescent microglia has been highlighted as a critical
contributor to the progression of tauopathies. Irisin, a muscle-derived hormone produced by …

Cardiometabolic diseases (CMDs) are interrelated and multifactorial conditions, including
arterial hypertension, type 2 diabetes, heart failure, coronary artery disease, and stroke. Due …