Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges

CY Loh, JY Chai, TF Tang, WF Wong, G Sethi… - Cells, 2019 - mdpi.com
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance

N Erin, J Grahovac, A Brozovic, T Efferth - Drug Resistance Updates, 2020 - Elsevier
It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

Context-dependent EMT programs in cancer metastasis

NM Aiello, Y Kang - Journal of Experimental Medicine, 2019 - rupress.org
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …

Molecular mechanisms of epithelial–mesenchymal transition

S Lamouille, J Xu, R Derynck - Nature reviews Molecular cell biology, 2014 - nature.com
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

E Kozhemyakina, AB Lassar, E Zelzer - Development, 2015 - journals.biologists.com
Decades of work have identified the signaling pathways that regulate the differentiation of
chondrocytes during bone formation, from their initial induction from mesenchymal …

Signaling mechanisms of the epithelial-mesenchymal transition

DM Gonzalez, D Medici - Science signaling, 2014 - science.org
The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic
development and tissue repair. EMT also contributes to the progression of disease …

Signal transduction pathways of EMT induced by TGF-β, SHH, and WNT and their crosstalks

J Zhang, XJ Tian, J Xing - Journal of clinical medicine, 2016 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing,
and cancer development. It involves cooperation of signaling pathways, such as …

[HTML][HTML] Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability

X Lei, Z Li, Y Zhong, S Li, J Chen, Y Ke, S Lv… - … Pharmaceutica Sinica B, 2022 - Elsevier
Metastasis is crucial for the mortality of non-small cell lung carcinoma (NSCLC) patients. The
epithelial–mesenchymal transition (EMT) plays a critical role in regulating tumor metastasis …

Therapeutic implications of cancer epithelial-mesenchymal transition (EMT)

ES Cho, HE Kang, NH Kim, JI Yook - Archives of pharmacal research, 2019 - Springer
The epithelial-mesenchymal transition (EMT) comprises an essential biological process
involving cancer progression as well as initiation. While the EMT has been regarded as a …