Haematopoietic stem cell transplantation for autoimmune diseases

JF Swart, EM Delemarre, F Van Wijk… - Nature Reviews …, 2017 - nature.com
Autologous haematopoietic stem cell transplantation (HSCT) is the only treatment that is
able to induce long-term, drug-free and symptom-free remission in several refractory …

Mesenchymal stem cells: allogeneic MSC may be immunosuppressive but autologous MSC are dysfunctional in lupus patients

RJ Cheng, AJ Xiong, YH Li, SY Pan… - Frontiers in cell and …, 2019 - frontiersin.org
Mesenchymal stem cells (MSCs) have a potently immunosuppressive capacity in both
innate and adaptive immune responses. Consequently, MSCs transplantation has emerged …

Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial

JM Van Laar, D Farge, JK Sont, K Naraghi… - Jama, 2014 - jamanetwork.com
Importance High-dose immunosuppressive therapy and autologous hematopoietic stem cell
transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small …

Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial

HL Atkins, M Bowman, D Allan, G Anstee, DL Arnold… - The Lancet, 2016 - thelancet.com
Background Strong immunosuppression, including chemotherapy and immune-depleting
antibodies followed by autologous haemopoietic stem-cell transplantation (aHSCT), has …

Safety analysis in patients with autoimmune disease receiving allogeneic mesenchymal stem cells infusion: a long-term retrospective study

J Liang, H Zhang, W Kong, W Deng, D Wang… - Stem Cell Research & …, 2018 - Springer
Objective The aim of this study was to evaluate the safety of mesenchymal stem cell infusion
in patients with autoimmune diseases. Methods A total of 404 patients with autoimmune …

Myasthenia gravis treated with autologous hematopoietic stem cell transplantation

A Bryant, H Atkins, CE Pringle, D Allan… - JAMA …, 2016 - jamanetwork.com
Importance Some patients with myasthenia gravis (MG) do not respond to conventional
treatment and have severe or life-threatening symptoms. Alternate and emerging therapies …

[HTML][HTML] Hematopoietic stem cell therapy for multiple sclerosis: top 10 lessons learned

HL Atkins, MS Freedman - Neurotherapeutics, 2013 - Elsevier
Reports from more than 600 hematopoietic stem cell transplants (HSCT) have appeared in
the medical literature for the last 1 and one-half decades. The patient's own stem cells are …

[HTML][HTML] Systemic sclerosis as an indication for autologous hematopoietic cell transplantation: position statement from the American Society for Blood and Marrow …

KM Sullivan, NS Majhail, C Bredeson… - Biology of Blood and …, 2018 - Elsevier
Systemic sclerosis is a progressive inflammatory disease that is frequently fatal and has
limited treatment options. High-dose chemotherapy with autologous hematopoietic cell …

Autologous haematopoietic stem cell transplantation in multiple sclerosis: a review of current literature and future directions for transplant haematologists and …

J Das, B Sharrack, JA Snowden - Current Hematologic Malignancy …, 2019 - Springer
Abstract Purpose of Review We summarise the current development of autologous
haematopoietic stem cell transplantation (AHSCT) in treating multiple sclerosis (MS) and …

Fertility preservation in patients with hematologic malignancies and recipients of hematopoietic cell transplants

AW Loren, S Senapati - Blood, The Journal of the American …, 2019 - ashpublications.org
Patients with hematologic malignancies and those undergoing hematopoietic cell
transplantation (HCT) face a complex set of challenges when considering options for fertility …