Immune modulation by human secreted RNases at the extracellular space
The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses
eight functional members in humans. The proteins are secreted by diverse innate immune …
eight functional members in humans. The proteins are secreted by diverse innate immune …
Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3–mediated gene silencing
tRNA fragments (tRFs) and tRNA halves have been implicated in various cellular processes,
including gene silencing, translation, stress granule assembly, cell differentiation …
including gene silencing, translation, stress granule assembly, cell differentiation …
Neuron‐specific translational control shift ensures proteostatic resilience during ER stress
K Wolzak, A Nölle, M Farina, TEM Abbink… - The EMBO …, 2022 - embopress.org
Proteostasis is essential for cellular survival and particularly important for highly specialised
post‐mitotic cells such as neurons. Transient reduction in protein synthesis by protein kinase …
post‐mitotic cells such as neurons. Transient reduction in protein synthesis by protein kinase …
Signaling to and from the RNA polymerase III transcription and processing machinery
IM Willis, RD Moir - Annual review of biochemistry, 2018 - annualreviews.org
RNA polymerase (Pol) III has a specialized role in transcribing the most abundant RNAs in
eukaryotic cells, transfer RNAs (tRNAs), along with other ubiquitous small noncoding RNAs …
eukaryotic cells, transfer RNAs (tRNAs), along with other ubiquitous small noncoding RNAs …
Mechanisms linking endoplasmic reticulum (ER) stress and microRNAs to adipose tissue dysfunction in obesity
KR Menikdiwela, JP Torres Guimaraes… - Critical Reviews in …, 2021 - Taylor & Francis
Over accumulation of lipids in adipose tissue disrupts metabolic homeostasis by affecting
cellular processes. Endoplasmic reticulum (ER) stress is one such process affected by …
cellular processes. Endoplasmic reticulum (ER) stress is one such process affected by …
IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A
M Gebert, S Bartoszewska, L Opalinski… - Cell Communication and …, 2023 - Springer
The unfolded protein response is a survival signaling pathway that is induced during various
types of ER stress. Here, we determine IRE1's role in miRNA regulation during ER stress …
types of ER stress. Here, we determine IRE1's role in miRNA regulation during ER stress …
[HTML][HTML] Tailoring the stress response of human skin cells by substantially limiting the nuclear localization of angiogenin
Human angiogenin (hANG) is the most studied stress-induced ribonuclease (RNase). In
physiological conditions it performs its main functions in nucleoli, promoting cell proliferation …
physiological conditions it performs its main functions in nucleoli, promoting cell proliferation …
Huntingtin and its role in mechanisms of RNA-mediated toxicity
A Heinz, DK Nabariya, S Krauss - Toxins, 2021 - mdpi.com
Huntington's disease (HD) is caused by a CAG-repeat expansion mutation in the Huntingtin
(HTT) gene. It is characterized by progressive psychiatric and neurological symptoms in …
(HTT) gene. It is characterized by progressive psychiatric and neurological symptoms in …
Schlafen 11 restricts flavivirus replication
F Valdez, J Salvador, PM Palermo, JE Mohl… - Journal of …, 2019 - Am Soc Microbiol
ABSTRACT Schlafen 11 (Slfn11) is an interferon-stimulated gene that controls the synthesis
of proteins by regulating tRNA abundance. Likely through this mechanism, Slfn11 has …
of proteins by regulating tRNA abundance. Likely through this mechanism, Slfn11 has …