NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart,
liver and pancreas. However, chronically elevated plasma FFA appear to have …

Recent studies provide clues regarding the cellular mechanisms that determine whether
excess lipid accumulation is well tolerated or cytotoxic. Critical in this process are …

ContextCare of patients with type 2 diabetes has been revolutionized throughout the past
several years—first, by the realization of the importance of tight glycemic control in …

To examine the mechanism by which moderate weight reduction improves basal and insulin-
stimulated rates of glucose metabolism in patients with type 2 diabetes, we used 1H …

Type 2 diabetes mellitus is a major cause of morbidity and mortality worldwide, and the
prevalence is set to increase dramatically over the coming decades. Understanding the …

Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and
visceral fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered …

Insulin resistance is a principal feature of type 2 diabetes and precedes the clinical
development of the disease by 10 to 20 years. Insulin resistance is caused by the decreased …

We examined the effect of three months of rosiglitazone treatment (4 mg bid) on whole-body
insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol …

Background Implanted spinal neuromodulation (SNMD) techniques are used in the
treatment of refractory chronic pain. They involve the implantation of electrodes around the …