“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Human evolution suggests that the default position for health is to be physically active.
Inactivity, by contrast, has serious negative effects on health across the lifespan. Therefore …

Sarcopenia reflects a progressive withdrawal of anabolism and an increased catabolism,
along with a reduced muscle regeneration capacity. Muscle force and power decline more …

Situations such as the recovery from injury and illness can lead to enforced periods of
muscle disuse or unloading. Such circumstances lead to rapid skeletal muscle atrophy, loss …

Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint
immobilization and bed rest, and is induced by a combination of unloading and inactivity …

Aging has been associated with a reduced muscle protein synthetic response to protein
intake, termed “anabolic resistance.” Physical activity performed before protein intake …

Prolonged skeletal muscle inactivity (eg limb immobilization, bed rest, mechanical
ventilation, spinal cord injury, etc.) results in muscle atrophy that manifests into a decreased …

In accordance with recent mechanistic advances, we recommend an applied, broad-based
two-phase approach to limit inactivity-mediated losses of muscle mass and function in older …

Our understanding of the potential benefits and challenges of optimizing dietary protein
intake in older adults continues to evolve. An overarching hypothesis generated during …

The ever increasing burden of an aging population and pandemic of metabolic syndrome
worldwide demands further understanding of the modifiable risk factors in reducing disability …