Fosfomycin, a natural product antibiotic, has been in use for> 20 years in Spain, Germany,
France, Japan, Brazil, and South Africa for urinary tract infections (UTIs) and other …

Fosfomycin has been used for the treatment of infections due to susceptible and multidrug-
resistant (MDR) bacteria. It inhibits bacterial cell wall synthesis through a unique mechanism …

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

Low molecular weight (LMW) thiols function as thiol-redox buffers to maintain the reduced
state of the cytoplasm. The best studied LMW thiol is the tripeptide glutathione (GSH) …

Background Soil is an important reservoir of antibiotic resistance genes (ARGs), but their
potential risk in different ecosystems as well as response to anthropogenic land use change …

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human
pathogens with the potential to cause significant morbidity and mortality. MRSA has …

Low molecular weight (LMW) thiols play an important role as thiol-cofactors for many
enzymes and are crucial to maintain the reduced state of the cytoplasm. Most Gram-negative …

Bacterial and fungal pathogens cause a variety of infectious diseases and constitute a
significant threat to public health. The human innate immune system represents the first line …

Neonatal sepsis causes up to an estimated 680,000 deaths annually worldwide,
predominantly in low-and middle-income countries (LMICs). A significant and growing …

Abstract Low-molecular-weight (LMW) thiols are produced in all living cells in different forms
and concentrations. Glutathione (GSH), coenzyme A (CoASH), bacillithiol (BSH), mycothiol …