Inflammatory and microbiota-related regulation of the intestinal epithelial barrier

G Barbara, MR Barbaro, D Fuschi, M Palombo… - Frontiers in …, 2021 - frontiersin.org
The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

DH Vasant, PA Paine, CJ Black, LA Houghton… - Gut, 2021 - gut.bmj.com
Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders
seen by clinicians in both primary and secondary care. Since publication of the last British …

Somatosensory and autonomic neuronal regulation of the immune response

S Udit, K Blake, IM Chiu - Nature Reviews Neuroscience, 2022 - nature.com
Bidirectional communication between the peripheral nervous system (PNS) and the immune
system is a crucial part of an effective but balanced mammalian response to invading …

Local immune response to food antigens drives meal-induced abdominal pain

J Aguilera-Lizarraga, MV Florens, MF Viola, P Jain… - Nature, 2021 - nature.com
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal, leading
to decreased quality of life, substantial morbidity and high medical costs. Although the …

[HTML][HTML] The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes

A Jacobson, D Yang, M Vella, IM Chiu - Mucosal immunology, 2021 - Elsevier
The gastrointestinal tract is densely innervated by a complex network of neurons that
coordinate critical physiological functions. Here, we summarize recent studies investigating …

Essential oils: Chemistry and pharmacological activities

DP de Sousa, ROS Damasceno, R Amorati… - Biomolecules, 2023 - mdpi.com
In this review, we provide an overview of the current understanding of the main mechanisms
of pharmacological action of essential oils and their components in various biological …

Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice

G De Palma, C Shimbori, DE Reed, Y Yu… - Science Translational …, 2022 - science.org
The gut microbiota has been implicated in chronic pain disorders, including irritable bowel
syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed …

Bowel disorders

BE Lacy, F Mearin, L Chang, WD Chey, AJ Lembo… - Gastroenterology, 2016 - Elsevier
Functional bowel disorders are highly prevalent disorders found worldwide. These disorders
have the potential to affect all members of society, regardless of age, sex, race, creed, color …

[HTML][HTML] What is new in Rome IV

MJ Schmulson, DA Drossman - Journal of neurogastroenterology …, 2017 - ncbi.nlm.nih.gov
Functional gastrointestinal disorders (FGIDs) are diagnosed and classified using the Rome
criteria; the criteria may change over time as new scientific data emerge. The Rome IV was …