Apoptotic cell death in disease—Current understanding of the NCCD 2023

I Vitale, F Pietrocola, E Guilbaud… - Cell Death & …, 2023 - nature.com
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

R Singh, A Letai, K Sarosiek - Nature reviews Molecular cell biology, 2019 - nature.com
The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

BCL-2 family proteins: changing partners in the dance towards death

J Kale, EJ Osterlund, DW Andrews - Cell Death & Differentiation, 2018 - nature.com
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …

Targeting apoptotic pathways for cancer therapy

X Tian, PR Srinivasan, V Tajiknia… - The Journal of clinical …, 2024 - jci.org
Apoptosis is a form of programmed cell death that is mediated by intrinsic and extrinsic
pathways. Dysregulation of and resistance to cell death are hallmarks of cancer. For over …

MOMP, cell suicide as a BCL-2 family business

H Kalkavan, DR Green - Cell Death & Differentiation, 2018 - nature.com
Apoptosis shapes development and differentiation, has a key role in tissue homeostasis,
and is deregulated in cancer. In most cases, successful apoptosis is triggered by …

An overview of apoptosis assays detecting DNA fragmentation

P Majtnerová, T Roušar - Molecular biology reports, 2018 - Springer
Apoptosis has been recognized as a type of programmed cell death connected with
characteristic morphological and biochemical changes in cells. This programmed cell death …

[HTML][HTML] AMPK: potential therapeutic target for ischemic stroke

S Jiang, T Li, T Ji, W Yi, Z Yang, S Wang, Y Yang… - Theranostics, 2018 - ncbi.nlm.nih.gov
AMP-activated protein kinase (AMPK), a member of the serine/threonine (Ser/Thr) kinase
group, is universally distributed in various cells and organs. It is a significant endogenous …

Agrocybe cylindracea fucoglucogalactan induced lysosome-mediated apoptosis of colorectal cancer cell through H3K27ac-regulated cathepsin D

Z Wang, K Chen, K Zhang, K He, D Zhang, X Guo… - Carbohydrate …, 2023 - Elsevier
Inducing lysosomal dysfunction is emerging as a promising means for cancer therapy.
Agrocybe cylindracea fucoglucogalactan (ACP) is a bioactive ingredient with anti-tumor …

The role of MiRNA in cancer: pathogenesis, diagnosis, and treatment

E Uzuner, GT Ulu, SB Gürler, Y Baran - miRNomics: MicroRNA Biology …, 2022 - Springer
Cancer is also determined by the alterations of oncogenes and tumor suppressor genes.
These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers …