In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …

Peripheral nerves contain large myelinated and small unmyelinated (Remak) fibers that
perform different functions. The choice to myelinate or not is dictated to Schwann cells by the …

Myelin is essential to nervous system function, playing roles in saltatory conduction and
trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central …

Myelination is essential for nervous system function. Schwann cells interact with neurons
and the basal lamina to myelinate axons using known receptors, signals and transcription …

Spinocerebellar ataxia Type 3 (SCA3), the most common dominantly inherited ataxia, is a
polyglutamine neurodegenerative disease for which there is no disease-modifying therapy …

Stem cells play a critical role in peripheral nerve regeneration. Nerve scaffolds fabricated by
specific materials can help induce the neurogenic differentiation of stem cells. Therefore, it is …

Hearing loss (HL) is the most common and heterogeneous disorder of the sensory system,
with a large morbidity in the worldwide population. Among cells of the acoustic nerve (VIII …

Injuries and diseases of the peripheral nervous system (PNS) are common but frequently
irreversible. It is often but mistakenly assumed that peripheral neuron regeneration is robust …

Schwann cells play a critical role in the development of the peripheral nervous system
(PNS), establishing important relationships both with the extracellular milieu and other cell …