Schizophrenia is a serious mental illness with chronic symptoms and significant impairment
in psychosocial functioning. Although novel antipsychotics have been developed, the …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

Vascular endothelial growth factor (VEGF) is a hypoxia-induced angiogenic protein that
exhibits a broad range of neurotrophic and neuroprotective effects in the central nervous …

Accumulation of abnormally integrated, adult-born, hippocampal dentate granule cells
(DGCs) is hypothesized to contribute to the development of temporal lobe epilepsy (TLE) …

There is a long history that protracted periods of circadian disruption, such as through
frequent transmeridian travel or rotating shift work, can have a significant impact on brain …

We have hypothesized that a downregulation of reelin and deficient maturation of adult-born
hippocampal neurons are important factors in the pathogenesis of depression. This …

We have hypothesized that the extracellular matrix protein reelin is involved in the
pathogenesis of major depression. This hypothesis is based on previous work in which we …

Studies of epilepsy have mainly focused on the membrane proteins that control neuronal
excitability. Recently, attention has been shifting to intracellular proteins and their …

Adult neurogenesis, the generation of new neurons in the adult brain, occurs in the
hippocampal dentate gyrus (DG) and the olfactory bulb (OB) of all mammals, but the …

Alzheimer's disease (AD) accounts for most dementia cases, but we lack a complete
understanding of the mechanisms responsible for the core pathology associated with the …