Excessive, chronic alcohol consumption can lead to alcoholic liver disease. The etiology of
alcoholic liver disease is multifactorial and is influenced by alterations in gene expression …

Exposure to environmentally relevant chemicals that activate the xenobiotic receptors aryl
hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and peroxisome …

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease; however,
progression to nonalcoholic steatohepatitis (NASH) is associated with most adverse …

The pregnane X receptor (PXR, NR1I2), a xenobiotic-sensing nuclear receptor signaling
potentiates ethanol (EtOH)-induced hepatotoxicity in male mice, however, how PXR …

Targeted mutant models are common in mechanistic toxicology experiments investigating
the absorption, metabolism, distribution, or elimination (ADME) of chemicals from …

Environmental pollution is increasingly considered an important factor involved in the
obesity incidence. Endocrine disruptors (EDs) are important actors in the concept of DOHaD …

Obesity is an endemic problem in the United States and elsewhere, and data indicate that in
addition to overconsumption, exposure to specific chemicals enhances obesity. CYP2B …

The ability to knock out and/or humanize different genes in experimental animals, globally or
in cell-and tissue-specific patterns, has revolutionized scientific research in many areas …

Plasma lipids are modulated by gene variants and many environmental factors, including
diet-associated weight gain. However, understanding how these factors jointly interact to …

Recent studies indicate a role for the constitutive androstane receptor (CAR), pregnane X-
receptor (PXR), and hepatic xenobiotic detoxifying CYPs in fatty liver disease or obesity …