Next‐generation antimalarial drugs: hybrid molecules as a new strategy in drug design

FW Muregi, A Ishih - Drug development research, 2010 - Wiley Online Library
Malaria is a disease that affects nearly 40% of the global population, and chemotherapy
remains the mainstay of its control strategy. The global malaria situation is increasingly …

Falcipains and other cysteine proteases of malaria parasites

PJ Rosenthal - Cysteine proteases of pathogenic organisms, 2011 - Springer
A number of cysteine proteases of malaria parasites have been described and many more
are suggested by analysis of the Plasmodium falciparum genome sequence. The best …

[HTML][HTML] Current antimalarial therapies and advances in the development of semi-synthetic artemisinin derivatives

L Pinheiro, LM Feitosa, FF SILVEIRA… - Anais da Academia …, 2018 - SciELO Brasil
ABSTRACT According to the World Health Organization, malaria remains one of the biggest
public health problems in the world. The development of resistance is a current concern …

Peroxides with anthelmintic, antiprotozoal, fungicidal and antiviral bioactivity: properties, synthesis and reactions

VA Vil', IA Yaremenko, AI Ilovaisky, AO Terent'ev - Molecules, 2017 - mdpi.com
The biological activity of organic peroxides is usually associated with the antimalarial
properties of artemisinin and its derivatives. However, the analysis of published data …

Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research

OPS Patel, RM Beteck, LJ Legoabe - European journal of medicinal …, 2021 - Elsevier
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …

Traditional herbal antimalarial therapy in Kilifi district, Kenya

JW Gathirwa, GM Rukunga, PG Mwitari… - Journal of …, 2011 - Elsevier
AIM OF STUDY: To identify plant species used by the traditional health practitioners (THPs)
in treatment of malaria, carry out cytotoxicity and efficacy evaluation of the identified plants …

Copper catalyzed cyano-sulfonylation of allenes via the insertion of sulfur dioxide toward the synthesis of (E)-α-cyanomethyl vinylsulfones

Y Li, X Zhang, Z Lian - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
An efficient and practical method for highly regio-and stereo-selective cyanosulfonylation of
allenes by inserting sulfur dioxide to synthesize useful (E)-α-cyanomethyl vinylsulfones has …

Are antimalarial hybrid molecules a close reality or a distant dream?

D Agarwal, RD Gupta, SK Awasthi - Antimicrobial agents and …, 2017 - Am Soc Microbiol
Emergence of drug-resistant Plasmodium falciparum strains has led to a situation of haste in
the scientific and pharmaceutical communities. Hence, all their efforts are redirected toward …

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

R Capela, GG Cabal, PJ Rosenthal, J Gut… - Antimicrobial agents …, 2011 - Am Soc Microbiol
It is widely accepted that the struggle against malaria depends on the development of new
strategies to fight infection. The “magic bullet” thought to be necessary to reach eradication …

From hybrid compounds to targeted drug delivery in antimalarial therapy

R Oliveira, D Miranda, J Magalhaes, R Capela… - Bioorganic & medicinal …, 2015 - Elsevier
The discovery of new drugs to treat malaria is a continuous effort for medicinal chemists due
to the emergence and spread of resistant strains of Plasmodium falciparum to nearly all …