Animal models of acute exacerbation of pulmonary fibrosis

X Ye, M Zhang, H Gu, M Liu, Y Zhao, Y Shi, S Wu… - Respiratory …, 2023 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease
with an unknown cause. Some patients may experience acute exacerbations (AE), which …

Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis

Y Wang, W Yang, L Liu, L Liu, J Chen, L Duan, Y Li… - Plos one, 2023 - journals.plos.org
Acute lung injury (ALI) is a life-threatening disease that has received considerable critical
attention in the field of intensive care. This study aimed to explore the role and mechanism of …

[HTML][HTML] Ethnopharmacology, phytochemistry, pharmacology, and product application of Platycodon grandiflorum: A review

L Zhang, X Wang, J Zhang, D Liu, G Bai - Chinese Herbal Medicines, 2024 - Elsevier
Abstract Platycodonis radix (Jiegeng in Chinese) is a well-known traditional Chinese
medicine used for both medicinal and culinary purposes. Its historical use as an antitussive …

Integrated network pharmacology, molecular docking, and lipidomics to reveal the regulatory effect of Qingxuan Zhike granules on lipid metabolism in …

H Chen, J Chen, L Feng, H Shao… - Biomedical …, 2024 - Wiley Online Library
Qingxuan Zhike granules (QXZKG), a traditional Chinese patent medication, has shown
therapeutic potential against acute lung injury (ALI). However, the precise mechanism …

Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM2.5-Induced Lung Injury by Inhibiting the TLR4/NF-κB p65 Pathway and Regulating the Lung and …

Y Sun, Y Wang, Z Yang, X Han, Y Zhang… - Journal of Agricultural …, 2024 - ACS Publications
Platycodonis radix (PR) has been reported to play a protective role in lung injury. However,
much less is known about the protective effect and mechanism of its main component PR …

[HTML][HTML] Medicinal Herbal Extracts: Therapeutic Potential in Acute Lung Injury

JW Lee, HJ Lee, SH Yun, J Lee, H Kim, HY Kang… - Future …, 2024 - mdpi.com
Acute lung injury (ALI) is induced by pneumonia, sepsis and other conditions. The disease
characteristics include severe lung inflammation, in which various cells, such as epithelial …

Qingfei Huoxue Decoction and Its Active Component Narirutin Alleviate LPS-Induced Acute Lung Injury by Regulating TLR4/NF-κB Pathway Mediated Inflammation

Y Wang, B Li, Y Zhang, R Lu, Q Wang… - Journal of Inflammation …, 2024 - Taylor & Francis
Background Acute lung injury (ALI) is a life-threatening clinical syndrome with high mortality.
Currently, the safe and effective therapies for ALI patients are still limited. Qingfei Huoxue …

Effect of Developmental Stages on the Biosynthesis of Triterpene Saponins and Related Gene Expression in Seedlings of Platycodon grandiflorus

Y Liu, W Ren, Z Wang, J Lu, X Su… - Natural Product …, 2023 - journals.sagepub.com
Objective: To investigate the impact of developmental stages on triterpene saponin content
and expression of key genes in their biosynthetic pathway in Platycodon grandiflorus …