Bacteriophage-encoded virion-associated enzymes to overcome the carbohydrate barriers during the infection process

A Latka, B Maciejewska, G Majkowska-Skrobek… - Applied microbiology …, 2017 - Springer
Bacteriophages are bacterial viruses that infect the host after successful receptor recognition
and adsorption to the cell surface. The irreversible adherence followed by genome material …

Learning from bacteriophages-advantages and limitations of phage and phage-encoded protein applications

Z Drulis-Kawa, G Majkowska-Skrobek… - Current Protein and …, 2012 - ingentaconnect.com
The emergence of bacteria resistance to most of the currently available antibiotics has
become a critical therapeutic problem. The bacteria causing both hospital and community …

Bacteriophages and phage-derived proteins–application approaches

Z Drulis-Kawa, G Majkowska-Skrobek… - Current medicinal …, 2015 - ingentaconnect.com
Currently, the bacterial resistance, especially to most commonly used antibiotics has proved
to be a severe therapeutic problem. Nosocomial and community-acquired infections are …

Hyaluronidases, a group of glycosidases: Current and future perspectives

NS El-Safory, AE Fazary, CK Lee - Carbohydrate polymers, 2010 - Elsevier
Given the constant synthesis and degradation of hyaluronan (hyaluronic acid, HA) in tissues,
it is remarkable that the human body maintains precise levels of hyaluronan as tightly as it …

Hyaluronidases and hyaluronate lyases: From humans to bacteriophages

M Sindelar, J Jilkova, L Kubala, V Velebny… - Colloids and Surfaces B …, 2021 - Elsevier
Hyaluronan is a non-sulfated negatively-charged linear polymer distributed in most parts of
the human body, where it is located around cells in the extracellular matrix of connective …

A heterodimeric hyaluronate lyase secreted by the activated sludge bacterium Haliscomenobacter hydrossis

T Mori, N Masuzawa, K Kondo… - Bioscience …, 2023 - academic.oup.com
Haliscomenobacter hydrossis is a filamentous bacterium common in activated sludge. The
bacterium was found to utilize hyaluronic acid, and hyaluronate lyase activity was detected …

A comprehensive review on microbial hyaluronan-degrading enzymes: from virulence factors to biotechnological tools

JY Jiang, D Xue, JS Gong, QX Zheng, YS Zhang… - Bioresources and …, 2024 - Springer
Hyaluronan (HA), a natural high molecular weight polysaccharide, has extensive
applications in cosmetology and medical treatment. Hyaluronan-degrading enzymes (Hyals) …

Polysaccharide binding sites in hyaluronate lyase–crystal structures of native phage–encoded hyaluronate lyase and its complexes with ascorbic acid and lactose

P Mishra, R Prem Kumar, AS Ethayathulla… - The FEBS …, 2009 - Wiley Online Library
Hyaluronate lyases are a class of endoglycosaminidase enzymes with a high level of
complexity and heterogeneity. The main function of the Streptococcus pyogenes …

Characterization of hyaluronic acid specific hyaluronate lyase (HylP) from Streptococcus pyogenes

SK Singh, S Malhotra, MS Akhtar - Biochimie, 2014 - Elsevier
Streptococcus pyogenes is associated with a wide variety of mucosal and invasive infections
that claim human life. The conversion from non pathogenic to toxigenic strain of S. pyogenes …

Cytotoxic and antioxidant effects of unsaturated hyaluronic acid oligomers

NS El-Safory, CK Lee - Carbohydrate polymers, 2010 - Elsevier
Hyaluronate lyase cleaves hyaluronan chains at a β-d-GalNAc-(1→ 4)-β-d-GlcA bond,
ultimately breaking the polysaccharide down to 3-(4-deoxy-β-d-gluc-4-enuronosyl)-N-acetyl …