The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality
worldwide. Its complexity is influenced by various signal transduction networks that govern …

Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …

Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic
traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) …

Gastric and small intestinal organoids differentiated from human pluripotent stem cells
(hPSCs) have revolutionized the study of gastrointestinal development and disease. Distal …

The mammalian intestine is covered by a single layer of epithelial cells that is renewed
every 4–5 days. This high cell turnover makes it a very attractive and comprehensive adult …

Interactions between tumour cells and the surrounding microenvironment contribute to
tumour progression, metastasis and recurrence,–. Although mosaic analyses in Drosophila …

Hereditary mixed polyposis syndrome (HMPS) is characterized by the development of mixed-
morphology colorectal tumors and is caused by a 40-kb genetic duplication that results in …

We address the mechanism by which adult intestinal stem cells (ISCs) become localized to
the base of each villus during embryonic development. We find that, early in gut …