Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are
27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA …

Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that
patients have received over the last 4 decades. Extensive efforts to identify more effective or …

Osteosarcoma is the most common primary malignancy of bone, typically presenting in the
first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients …

Overall survival of patients with osteosarcoma (OS) has improved little in the past three
decades, and better models for study are needed. OS is common in large dog breeds and is …

Osteosarcoma is an aggressive but ill‐understood cancer of bone that predominantly affects
adolescents. Its rarity and biological heterogeneity have limited studies of its molecular …

New genes commonly appear through complete or partial duplications of pre-existing
genes. Duplications of long DNA segments are constantly produced by rare mutations, may …

High‐grade osteosarcoma is a tumor with a complex genomic profile, occurring primarily in
adolescents with a second peak at middle age. The extensive genomic alterations obscure …

The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …