Mesothelioma affects mostly older individuals who have been occupationally exposed to
asbestos. The global mesothelioma incidence and mortality rates are unknown, because …

Substantial changes in the 2021 WHO Classification of Tumors of the Pleura and
Pericardium since the 2015 WHO Classification include the following:(1) pleural and …

Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

Malignant mesothelioma is a universally lethal cancer that is increasing in incidence
worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and …

Background Breast cancer 1-associated protein 1 (BAP1) is a nuclear deubiquitinase that
regulates gene expression, transcription, DNA repair, and more. Several findings …

Purpose We hypothesized that four criteria could help identify malignant mesotheliomas
(MMs) most likely linked to germline mutations of BAP1 or of other genes: family history of …

Carbon nanotubes (CNTs) are nanomaterials with broad applications that are produced on
a large scale. Animal experiments have shown that exposure to CNTs, especially one type …

Germline BAP1 mutations predispose to several cancers, in particular malignant
mesothelioma. Mesothelioma is an aggressive malignancy generally associated with …

We used a custom-made comparative genomic hybridization array (aCGH; average probe
interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy …

Abstract On November 9 and 10, 2015, the International Conference on Mesothelioma in
Populations Exposed to Naturally Occurring Asbestiform Fibers was held at the University of …