Modeling HIV-1 virus dynamics with both virus-to-cell infection and cell-to-cell transmission

X Lai, X Zou - SIAM Journal on Applied Mathematics, 2014 - SIAM
Direct cell-to-cell transfer of HIV-1 is found to be a more potent and efficient means of virus
propagation than virus-to-cell infection. In this paper we propose a mathematical model to …

Global stability of a nonlinear viral infection model with infinitely distributed intracellular delays and CTL immune responses

H Shu, L Wang, J Watmough - SIAM Journal on Applied Mathematics, 2013 - SIAM
Determining sharp conditions for the global stability of equilibria remains one of the most
challenging problems in the analysis of models for the management and control of biological …

A model of HIV-1 infection with two time delays: mathematical analysis and comparison with patient data

KA Pawelek, S Liu, F Pahlevani, L Rong - Mathematical Biosciences, 2012 - Elsevier
Mathematical models have made considerable contributions to our understanding of HIV
dynamics. Introducing time delays to HIV models usually brings challenges to both …

Global stability and Hopf bifurcation of an HIV-1 infection model with saturation incidence and delayed CTL immune response

X Tian, R Xu - Applied Mathematics and Computation, 2014 - Elsevier
In this paper, an HIV-1 infection model with saturation incidence and time delay due to the
CTL immune response is investigated. By analyzing corresponding characteristic equations …

Viral dynamics model with CTL immune response incorporating antiretroviral therapy

Y Wang, Y Zhou, F Brauer, JM Heffernan - Journal of mathematical biology, 2013 - Springer
We present two HIV models that include the CTL immune response, antiretroviral therapy
and a full logistic growth term for uninfected CD4^+ T-cells. The difference between the two …

[HTML][HTML] Global stability of in-host viral models with humoral immunity and intracellular delays

S Wang, D Zou - Applied Mathematical Modelling, 2012 - Elsevier
In this paper, we investigate the dynamical behavior of in-host viral models with humoral
immunity and intracellular delays. For both models, using the method of Lyapunov …

Threshold dynamics of HIV-1 virus model with cell-to-cell transmission, cell-mediated immune responses and distributed delay

J Wang, M Guo, X Liu, Z Zhao - Applied Mathematics and Computation, 2016 - Elsevier
The goal of this paper is to study the threshold dynamics of an HIV-1 viral infection model
with cell-mediated immune responses and direct cell-to-cell transmission mechanism. The …

Threshold dynamics of an HIV-1 virus model with both virus-to-cell and cell-to-cell transmissions, intracellular delay, and humoral immunity

J Lin, R Xu, X Tian - Applied mathematics and computation, 2017 - Elsevier
Direct cell-to-cell transmission of HIV-1 is proved to be a more efficient means of virus
infection than virus-to-cell transmission. In this paper, we incorporate both virus-to-cell and …

Optimal control of a delayed HIV infection model with immune response using an efficient numerical method

K Hattaf, N Yousfi - International Scholarly Research Notices, 2012 - Wiley Online Library
We present a delay‐differential equation model with optimal control that describes the
interactions between human immunodeficiency virus (HIV), CD4+ T cells, and cell‐mediated …

Global stability analysis for delayed virus infection model with general incidence rate and humoral immunity

T Wang, Z Hu, F Liao, W Ma - Mathematics and Computers in Simulation, 2013 - Elsevier
In this paper, we investigate the dynamical behavior of a virus infection model with general
incidence rate and humoral immunity. By using suitable Lyapunov functional and the …