Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

Background Neuroinflammation plays a vital role in the development and maintenance of
neuropathic pain. Recent evidence has proved that bone marrow mesenchymal stem cells …

BACKGROUND: In neuropathic pain following peripheral nerve injury, microglia are rapidly
activated and accumulated in the spinal cord. Physical exercise can alleviate neuropathic …

Satellite glial cells (SGCs) are homeostatic cells enveloping the somata of peripheral
sensory and autonomic neurons. A wide variety of neuronal stressors trigger activation of …

Pain is a common non-motor symptom of Parkinson's disease (PD), with current limited
knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha …

Carbon nanotubes (CNTs) have attracted increasing attention in the field of peripheral nerve
tissue engineering due to their unique structural and physical characteristics. In this study, a …

Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic
pain. Apparently contradictory mechanisms have been reported, raising questions on the …

Neuropathic pain (NPP) is a common syndrome associated with most forms of cancer, which
poses a serious threat to human health. NPP may persist even after the nociceptive …

Brain-derived neurotrophic factor (BDNF) is an important modulator for a variety of functions
in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and …