The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

Phosphorus‐substituted heterocycles represent an important class of organophosphorus
compounds, which not only widely exist in biologically active pharmaceuticals …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

Entamoeba histolytica, a protozoan intestinal parasite, is the causative agent of human
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …

The discovery and development of the bisphosphonates (BPs) as a major class of drugs for
the treatment of bone diseases has been a fascinating journey that is still not over. In clinical …

The bisphosphonates (BPs) are well established as the treatments of choice for disorders of
excessive bone resorption, including Paget's disease of bone, myeloma and bone …

A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

The “amitochondriate” protozoan parasites of humans Entamoeba histolytica, Giardia
intestinalis, and Trichomonas vaginalis share many biochemical features, eg, energy and …

Bisphosphonates, used for a long time in osteoporosis management, are currently the target
of intensive research, from pre-formulation studies to more advanced stages of clinical …