Bone remodeling in the adult skeleton facilitates the removal and replacement of damaged
and old bone to maintain bone quality. Tight coordination of bone resorption and bone …

Although biodegradable polymer coatings can impede corrosion of magnesium (Mg)-based
orthopedic implants, they are prone to excessive degradation and accidental scratching in …

Osteoporosis (OP), characterized by continuous bone loss and increased fracture risk, has
posed a challenge to patients and society. Long-term administration of current …

Introduction The aim of this study was to evaluate the anti-osteoclastic activity of calcium
hydroxide–loaded poly (lactic-co-glycolic acid) nanoparticles [Ca (OH) 2-loaded PLGA NPs] …

Rheumatoid arthritis (RA) is an autoimmune disease of the joint synovial membranes. RA is
difficult to prevent or treat; however, blocking proinflammatory cytokines is a general …

Histone methylation plays a crucial role in various cellular processes. We previously
reported the in vitro function of histone lysine demethylase 7 A (KDM7A) in osteoblast and …

Chronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic
lupus erythematosus, Crohn's disease, periodontitis, and carcinoma metastasis frequently …

Notch signaling is an evolutionary conserved pathway with a key role in tissue homeostasis,
differentiation and proliferation. It was reported that Notch1 receptor negatively regulates …

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs, n-3 PUFAs), including eicosapentaenoic
acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential …

Excessive activity of osteoclasts (OCs) lead to bone resorption in chronic inflammatory
conditions. The use of natural compounds to target OCs offers significant promise in the …