Malaria vaccines: progress to date

DI Stanisic, MF Good - BioDrugs, 2023 - Springer
Malaria is a mosquito-borne disease caused by protozoan parasites of the genus
Plasmodium. Despite significant declines in malaria-attributable morbidity and mortality over …

Malaria vaccines: from the past towards the mRNA vaccine era

ME Tsoumani, C Voyiatzaki, A Efstathiou - Vaccines, 2023 - mdpi.com
Plasmodium spp. is the etiological agent of malaria, a life-threatening parasitic disease
transmitted by infected mosquitoes. Malaria remains a major global health challenge …

Sporozoite immunization: innovative translational science to support the fight against malaria

TL Richie, LWP Church, T Murshedkar… - Expert review of …, 2023 - Taylor & Francis
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

Malaria vaccines: a new era of prevention and control

PE Duffy, JP Gorres, SA Healy, M Fried - Nature Reviews Microbiology, 2024 - nature.com
Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …

Strategic and scientific contributions of human challenge trials for vaccine development: facts versus fantasy

YN Abo, E Jamrozik, JS McCarthy… - The Lancet Infectious …, 2023 - thelancet.com
The unprecedented speed of delivery of SARS-CoV-2 pandemic vaccines has redefined the
limits for all vaccine development. Beyond the aspirational 100-day timeline for tomorrow's …

A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion

D Goswami, H Patel, W Betz, J Armstrong… - EMBO Molecular …, 2024 - embopress.org
Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with
antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection …

Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and-positive Tanzanian adults

S Jongo, LWP Church, F Milando… - The Journal of …, 2024 - Am Soc Clin Investig
BACKGROUND Sanaria PfSPZ Vaccine, composed of attenuated Plasmodium falciparum
(Pf) sporozoites (SPZ), protects against malaria. We conducted this clinical trial to assess the …

Vaccines and monoclonal antibodies: new tools for malaria control

K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Safety and efficacy of PfSPZ Vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomised, double-blind, placebo-controlled …

H Diawara, SA Healy, A Mwakingwe-Omari… - The Lancet Infectious …, 2024 - thelancet.com
Background Plasmodium falciparum parasitaemia during pregnancy causes maternal, fetal,
and infant mortality. Poor pregnancy outcomes are related to blood-stage parasite …

Malaria prevention in children: an update

DAJ Friedman-Klabanoff, D Adu-Gyasi… - Current Opinion in …, 2024 - journals.lww.com
While challenges remain in malaria control towards elimination, new guidelines and recently
approved vaccines offer hope. Monitoring for continued vaccine and chemoprevention …