The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Rationale Psychosocial stressors are a well-documented risk factor for mental illness.
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …

Tumor extracellular matrix has been associated with drug resistance and immune
suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung …

Background and Aims The development and progression of hepatocellular carcinoma
(HCC) is dependent on its local microenvironment. Tumor‐associated macrophages (TAMs) …

Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

The recognition of integrins as a widely expressed family of cell surface adhesion receptors
is around five years old (Hynes, 1987). At that time, one could identify about ten distinct …

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of cells that play a
critical role in tumor associated immune suppression. In an attempt to identify a specific …

Our failure to produce truly non-thrombogenic materials may reflect a failure to fully
understand the mechanisms of biomaterial-associated thrombosis. The community has …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Although circulating neutrophils are associated with distant metastasis and poor outcome in
a number of epithelial malignancies, it remains unclear whether neutrophils play an active …