Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

AW Caliri, S Tommasi, A Besaratinia - Mutation Research/Reviews in …, 2021 - Elsevier
Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …

Oxidative stress is the pivot for PM2. 5-induced lung injury

T Hou, L Zhu, Y Wang, L Peng - Food and Chemical Toxicology, 2024 - Elsevier
Abstract Fine particulate matter (PM2. 5) is a primary air pollutant recognized worldwide as a
serious threat to public health. PM2. 5, which has a diameter of less than 2.5 μm, is known to …

Oxidative stress in malaria: potential benefits of antioxidant therapy

ARQ Gomes, N Cunha, ELP Varela… - International Journal of …, 2022 - mdpi.com
Malaria is an infectious disease and a serious public health problem in the world, with 3.3
billion people in endemic areas in 100 countries and about 200 million new cases each …

Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes

AA Shamseddine, MV Airola, YA Hannun - Advances in biological …, 2015 - Elsevier
Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …

Presence of antioxidative agent, Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro- in newly isolated Streptomyces mangrovisoli sp. nov.

HL Ser, UD Palanisamy, WF Yin… - Frontiers in …, 2015 - frontiersin.org
A novel Streptomyces, strain MUSC 149T was isolated from mangrove soil. A polyphasic
approach was used to study the taxonomy of MUSC 149T, which shows a range of …

Role of sphingolipids in the pathobiology of lung inflammation

R Ghidoni, A Caretti, P Signorelli - Mediators of inflammation, 2015 - Wiley Online Library
Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle
them have been extensively investigated. Gas or inhaled particles or microorganisms come …

Mitochondrial dysfunction in human primary alveolar type II cells in emphysema

B Kosmider, CR Lin, L Karim, D Tomar, L Vlasenko… - …, 2019 - thelancet.com
Background Cigarette smoke is the main risk factor of pulmonary emphysema development,
which is characterized by alveolar wall destruction. Mitochondria are important for alveolar …

Personal PM2. 5 exposure and lung function: Potential mediating role of systematic inflammation and oxidative damage in urban adults from the general population

G Mu, M Zhou, B Wang, L Cao, S Yang, W Qiu… - Science of The Total …, 2021 - Elsevier
Background Short-term effects of fine particulate matter (PM 2.5) exposure on lung function
have been reported. However, few studies have assessed PM 2.5 exposure on the personal …

The double-edged sword profile of redox signaling: oxidative events as molecular switches in the balance between cell physiology and cancer

S Emanuele, A D'Anneo, G Calvaruso… - Chemical research in …, 2018 - ACS Publications
The intracellular redox state in the cell depends on the balance between the level of reactive
oxygen species (ROS) and the activity of defensive systems including antioxidant enzymes …

[HTML][HTML] The role of peroxiredoxin family in cancer signaling

Y Kim, HH Jang - Journal of cancer prevention, 2019 - ncbi.nlm.nih.gov
Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by
reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells …