CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

Galectins are glycan-binding proteins that contain one or two carbohydrate domains and
mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal …

Mucosal surfaces line our body cavities and provide the interaction surface between
commensal and pathogenic microbiota and the host. The barrier function of the mucosal …

The major cause of cancer-associated mortality is tumor metastasis, a disease that is far
from understood. Many studies have observed circulating tumor cells (CTCs) in patients' …

Galectin-3 is a mammalian β-galactoside-binding protein that is expressed by various types
of human cells. Changes in galectin-3 expression and subcellular and intercellular …

Galectin 3 is a member of a family of β-galactoside binding proteins and has emerged as an
important regulator of diverse functions critical in cancer biology including apoptosis …

Recent molecular classification of glioblastoma (GBM) has shown that patients with a
mesenchymal (MES) gene expression signature exhibit poor overall survival and treatment …

Mucins (MUC) are high molecular weight O-linked glycoproteins whose primary functions
are to hydrate, protect, and lubricate the epithelial luminal surfaces of the ducts within the …

Galectin-3, the only chimera galectin found in vertebrates, is one of the best-studied
galectins. It is expressed in several cell types and is involved in a broad range of …

The transformation from normal to malignant phenotype in human cancers is associated with
aberrant cell-surface glycosylation. It has frequently been reported that MUC1, the heavily …