Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice

RS Wallis, M Pai, D Menzies, TM Doherty, G Walzl… - The lancet, 2010 - thelancet.com
Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …

Diagnosis of extrapulmonary tuberculosis by PCR

PK Mehta, A Raj, N Singh… - FEMS Immunology & …, 2012 - academic.oup.com
During the last two decades, the resurgence of tuberculosis (TB) has been documented in
both developed and developing nations, and much of this increase in TB burden coincided …

Biomarkers for tuberculosis disease activity, cure, and relapse

RS Wallis, TM Doherty, P Onyebujoh… - The Lancet infectious …, 2009 - thelancet.com
New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …

Improved diagnostic value of PCR in the diagnosis of female genital tuberculosis leading to infertility

NV Bhanu, UB Singh, M Chakraborty… - Journal of medical …, 2005 - microbiologyresearch.org
Histopathological and mycobacteriological examinations have limited utility in the diagnosis
of genital tuberculosis. In this double-blind study, 61 samples, consisting of endometrial …

Toward the Development of a Circulating Free DNA-Based In Vitro Diagnostic Test for Infectious Diseases: a Review of Evidence for Tuberculosis

BL Fernández-Carballo, T Broger, R Wyss… - Journal of clinical …, 2019 - Am Soc Microbiol
The detection of circulating free DNA (cfDNA) has transformed the field of oncology and
prenatal diagnostics. Clinical application of cfDNA for disease diagnosis and monitoring …

The source and fate of Mycobacterium tuberculosis complex in wastewater and possible routes of transmission

HN Mtetwa, ID Amoah, S Kumari, F Bux, P Reddy - BMC Public Health, 2022 - Springer
Abstract Background The Mycobacterium tuberculosis complex (MTBC) consists of
causative agents of both human and animal tuberculosis and is responsible for over 10 …

Rapid diagnosis of tuberculosis through the detection of mycobacterial DNA in urine by nucleic acid amplification methods

C Green, JF Huggett, E Talbot, P Mwaba… - The Lancet infectious …, 2009 - thelancet.com
Tuberculosis kills over 1· 7 million people worldwide every year and nearly 40% of patients
with active tuberculosis remain undiagnosed because of the poor sensitivity of the current …

New diagnostics for childhood tuberculosis

SS Chiang, DS Swanson, JR Starke - Infectious Disease Clinics, 2015 - id.theclinics.com
Recent studies estimate that less than two-thirds of tuberculosis (TB) cases occurring in
childhood—defined by the World Health Organization (WHO) as 0 to 14 years of age—are …

Mycobacterium tuberculosis DNA detection in soluble fraction of urine from pulmonary tuberculosis patients

A Cannas, D Goletti, E Girardi… - … of tuberculosis and …, 2008 - ingentaconnect.com
SETTING: A tertiary care and research institution in Italy. BACKGROUND: Small DNA
fragments from cells dying throughout the body have been detected in urine (transrenal DNA …

Development of a loop-mediated isothermal amplification method for detection of Histoplasma capsulatum DNA in clinical samples

CM Scheel, Y Zhou, RC Theodoro… - Journal of clinical …, 2014 - Am Soc Microbiol
Improved methods for the detection of Histoplasma capsulatum are needed in regions with
limited resources in which the organism is endemic, where delayed diagnosis of progressive …