Galleria mellonella: The Versatile Host for Drug Discovery, In Vivo Toxicity Testing and Characterising Host-Pathogen Interactions

M Piatek, G Sheehan, K Kavanagh - Antibiotics, 2021 - mdpi.com
Larvae of the greater wax moth, Galleria mellonella, are a convenient in vivo model for
assessing the activity and toxicity of antimicrobial agents and for studying the immune …

[HTML][HTML] Open science approaches to COVID-19

GT Edwin, DM Klug, MH Todd - F1000Research, 2020 - ncbi.nlm.nih.gov
In only a matter of months, the coronavirus disease of 2019 (COVID-19) has spread around
the world. The global impact of the disease has caused significant and repeated calls for …

Crowdsourcing in medical research: concepts and applications

JD Tucker, S Day, W Tang, B Bayus - PeerJ, 2019 - peerj.com
Crowdsourcing shifts medical research from a closed environment to an open collaboration
between the public and researchers. We define crowdsourcing as an approach to problem …

Galleria mellonella for the Evaluation of Antifungal Efficacy against Medically Important Fungi, a Narrative Review

S Jemel, J Guillot, K Kallel, F Botterel, E Dannaoui - Microorganisms, 2020 - mdpi.com
The treatment of invasive fungal infections remains challenging and the emergence of new
fungal pathogens as well as the development of resistance to the main antifungal drugs …

The Use of Galleria mellonella Larvae to Identify Novel Antimicrobial Agents against Fungal Species of Medical Interest

K Kavanagh, G Sheehan - Journal of Fungi, 2018 - mdpi.com
The immune system of insects and the innate immune response of mammals share many
similarities and, as a result, insects may be used to assess the virulence of fungal pathogens …

Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of …

W Lim, B Nyuykonge, K Eadie, M Konings… - PLoS Neglected …, 2022 - journals.plos.org
Eumycetoma is a chronic subcutaneous neglected tropical disease that can be caused by
more than 40 different fungal causative agents. The most common causative agents produce …

UtilisingGalleria mellonella larvae for studying in vivo activity of conventional and novel antimicrobial agents

M Piatek, G Sheehan, K Kavanagh - Pathogens and Disease, 2020 - academic.oup.com
The immune response of insects displays many structural and functional similarities to the
innate immune response of mammals. As a result of these conserved features, insects may …

Leveraging the MMV Pathogen Box to Engineer an Antifungal Compound with Improved Efficacy and Selectivity against Candida auris

B Pan, H Weerasinghe, A Sezmis… - ACS Infectious …, 2023 - ACS Publications
Fungal infections pose a significant and increasing threat to human health, but the current
arsenal of antifungal drugs is inadequate. We screened the Medicines for Malaria Venture …

Identifying novel drugs with new modes of action for neglected tropical fungal skin diseases (fungal skinNTDs) using an Open Source Drug discovery approach

W Lim, A Verbon, W van de Sande - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction The three fungal skin neglected tropical diseases (NTD)–mycetoma,
chromoblastomycosis and sporotrichosis–currently lack prioritization and support to …

Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects

LYM Elkheir, R Haroun, MA Mohamed… - PLoS Neglected …, 2020 - journals.plos.org
Mycetoma is a WHO recognised neglected tropical disease that is a subcutaneous chronic
granulomatous progressively morbid inflammatory disease [1]. It frequently affects young …