A review on coronary artery disease, its risk factors, and therapeutics
AK Malakar, D Choudhury, B Halder… - Journal of cellular …, 2019 - Wiley Online Library
Coronary artery disease (CAD) is one of the major cardiovascular diseases affecting the
global human population. This disease has been proved to be the major cause of death in …
global human population. This disease has been proved to be the major cause of death in …
Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
Associations between blood type and COVID-19 infection, intubation, and death
The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and
testing resources, making the identification and prioritization of individuals most at-risk a …
testing resources, making the identification and prioritization of individuals most at-risk a …
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Nature genetics, 2015 - nature.com
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is
largely based on genome-wide association study (GWAS) analysis of common SNPs …
largely based on genome-wide association study (GWAS) analysis of common SNPs …
Genetics of coronary artery disease: discovery, biology and clinical translation
AV Khera, S Kathiresan - Nature Reviews Genetics, 2017 - nature.com
Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …
heritable, recent advances have started to unravel the genetic architecture of the disease …
Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
Aims While most patients with myocardial infarction (MI) have underlying coronary
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Heart failure is a leading cause of cardiovascular morbidity and mortality. However, the
contribution of common genetic variation to heart failure risk has not been fully elucidated …
contribution of common genetic variation to heart failure risk has not been fully elucidated …
ANGPTL3 deficiency and protection against coronary artery disease
Background: Familial combined hypolipidemia, a Mendelian condition characterized by
substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the …
substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …