Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

Synapses are often far from the soma and independently cope with proteopathic stress
induced by intense neuronal activity. However, how presynaptic compartments turn over …

The maintenance of synaptic transmission requires that vesicles be recycled after releasing
neurotransmitter. Several modes of retrieval have been proposed to operate at small …

Endophilin is a membrane-binding protein with curvature-generating and-sensing properties
that participates in clathrin-dependent endocytosis of synaptic vesicle membranes …

Endophilin‐A1 is a BAR domain‐containing protein enriched at synapses and is implicated
in synaptic vesicle endocytosis. It binds to dynamin and synaptojanin via a C‐terminal SH3 …

The function of the nervous system depends on the exocytotic release of neurotransmitter
from synaptic vesicles (SVs). To sustain neurotransmission, SV membranes need to be …

Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

Changes in the response to release of a single synaptic vesicle have generally been
attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now …