The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …

Vascular aging, a determinant factor for cardiovascular disease and health status in the
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …

Advancing age is the major risk factor for the development of CVD (cardiovascular
diseases). This is attributable, in part, to the development of vascular endothelial …

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium‐derived …

Macrophages play a paramount role in immunity and inflammation-associated diseases,
including infections, cardiovascular diseases, obesity-associated metabolic imbalances, and …

Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus
can either replicate without pathological consequences or trigger immune-mediated …

Patients with cancer have an impaired T‐cell response that can decrease the potential
therapeutic benefit of cancer vaccines and other forms of immunotherapy. l‐arginine (l‐Arg) …

Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on
cellular signal transduction and accumulating evidence indicates important roles for S …