The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects
L Xia, J Chen, J Huang, X Lin, J Jiang, T Liu, N Huang… - Heliyon, 2024 - cell.com
The AMP-activated protein kinase α (AMPKα) subunit is the catalytic subunit in the AMPK
complex, playing a crucial role in AMPK activation. It has two isoforms: AMPKα1 and …
complex, playing a crucial role in AMPK activation. It has two isoforms: AMPKα1 and …
CASK mediates oxidative stress-induced microglial apoptosis-inducing factor-independent parthanatos cell death via promoting PARP-1 hyperactivation and …
Calcium/calmodulin-dependent serine protein kinase (CASK) is a scaffold protein and plays
critical roles in neuronal synaptic formation and brain development. Previously, CASK was …
critical roles in neuronal synaptic formation and brain development. Previously, CASK was …
Role of AMPK-regulated autophagy in retinal pigment epithelial cell homeostasis: A review
L Zhou, Y Mo, H Zhang, M Zhang, J Xu, S Liang - Medicine, 2024 - journals.lww.com
The retinal pigment epithelium (RPE) is a regularly arranged monolayer of cells in the
outermost layer of the retina. It is crucial for transporting nutrients and metabolic substances …
outermost layer of the retina. It is crucial for transporting nutrients and metabolic substances …
Axonal protection by combination of ripasudil and brimonidine with upregulation of p-AMPK in TNF-induced optic nerve degeneration
M Otsubo, K Sase, C Tsukahara, N Fujita… - International …, 2024 - Springer
Purpose The ROCK inhibitor ripasudil hydrochloride hydrate was shown to have axonal
protective effects in TNF-induced optic nerve degeneration. The α2-adrenoreceptor agonist …
protective effects in TNF-induced optic nerve degeneration. The α2-adrenoreceptor agonist …
Combination of biotransformation and metabolomics reveals tolfenpyrad-induced hepatocytotoxicity
X Jiang, Y Zhu, S Dong, R Lin, P Zhu, J Mao… - Science of The Total …, 2024 - Elsevier
Tolfenpyrad (TFP) is an extensively used pesticide that inevitably leads to human exposure
to both TFP and its transformation product residues. However, the biotransformation of TFP …
to both TFP and its transformation product residues. However, the biotransformation of TFP …
NLRX1 Inhibits LPS-Induced Microglial Death via Inducing p62-Dependent HO-1 Expression, Inhibiting MLKL and Activating PARP-1
YL Huang, DY Huang, V Klochkov, CM Chan, YS Chen… - Antioxidants, 2024 - mdpi.com
The activation of microglia and the production of cytokines are key factors contributing to
progressive neurodegeneration. Despite the well-recognized neuronal programmed cell …
progressive neurodegeneration. Despite the well-recognized neuronal programmed cell …
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps
Y Lai, N Yang, D Shi, X Ma, Y Huang, J Lu… - European Journal of …, 2024 - Elsevier
Background and aim Necrosis of random-pattern flaps restricts their application in clinical
practice. Puerarin has come into focus due to its promising therapeutic effects in ischemic …
practice. Puerarin has come into focus due to its promising therapeutic effects in ischemic …