With the emergence of new viruses in the human population and the fast mutation rates of
existing viruses, new antiviral targets and compounds are needed. Most existing antiviral …

Alphaherpesviruses, as large double-stranded DNA viruses, were long considered to be
genetically stable and to exist in a homogeneous state. Recently, the proliferation of high …

Human herpes simplex virus 1 (HSV-1), a life-long infection spread by oral contact, infects a
majority of adults globally. Phylogeographic clustering of sampled diversity into European …

The crosstalk between the host's inflammasome system and the invading virulent/less-
virulent viruses determines the outcome of the ensuing inflammatory response. An …

Genomic rearrangements contribute to the enhancement of genetic diversity in populations.
However, non-canonical rearrangements (NCRs) such as deletions, insertions, and …

Importance Herpes simplex virus type 1 (HSV-1) is the leading cause of first-episode genital
herpes in many countries. Objective To inform counseling messages regarding genital HSV …

Purpose Herpes simplex virus (HSV) and varicella-zoster virus (VZV) are neurotropic human
alphaherpesviruses endemic worldwide. Upon primary infection, both viruses establish …

The large dsDNA virus herpes simplex virus 1 (HSV-1) is considered to be genetically
stable, yet it can rapidly evolve in response to strong selective pressures such as antiviral …

The arrival of novel sequencing technologies throughout the past two decades has led to a
paradigm shift in our understanding of herpesvirus genomic diversity. Previously …

Herpes simplex viruses (HSV) cause chronic infection in humans that are characterized by
periodic episodes of mucosal shedding and ulcerative disease. HSV causes millions of …