Immunoporosis: role of innate immune cells in osteoporosis

Y Saxena, S Routh, A Mukhopadhaya - Frontiers in immunology, 2021 - frontiersin.org
Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly
balanced physiological process known as 'bone remodeling'. The immune system is …

The rising era of “Immunoporosis”: Role of immune system in the pathophysiology of osteoporosis

RK Srivastava, L Sapra - Journal of Inflammation Research, 2022 - Taylor & Francis
Discoveries in the last few years have emphasized the existence of an enormous breadth of
communication between bone and the immune system in maintaining skeletal homeostasis …

Bifidobacterium longum Ameliorates Ovariectomy-Induced Bone Loss via Enhancing Anti-Osteoclastogenic and Immunomodulatory Potential of Regulatory B Cells …

L Sapra, N Shokeen, K Porwal, C Saini… - Frontiers in …, 2022 - frontiersin.org
Discoveries in the last few years have emphasized the existence of an enormous breadth of
communication between osteo-immune systems. These discoveries fuel novel approaches …

Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics

L Sapra, C Saini, B Garg, R Gupta, B Verma… - Inflammation …, 2022 - Springer
Background SARS-CoV-2 is a highly infectious respiratory virus associated with coronavirus
disease (COVID-19). Discoveries in the field revealed that inflammatory conditions exert a …

Unravelling the immunobiology of innate lymphoid cells (ILCs): Implications in health and disease

RK Srivastava, L Sapra, A Bhardwaj, PK Mishra… - Cytokine & Growth …, 2023 - Elsevier
Innate lymphoid cells (ILCs), a growing class of immune cells, imitate the appearance and
abilities of T cells. However, unlike T cells, ILCs lack acquired antigen receptors, and they …

“Osteomicrobiology”: the nexus between bone and bugs

A Bhardwaj, L Sapra, A Tiwari, PK Mishra… - Frontiers in …, 2022 - frontiersin.org
A growing body of scientific evidence supports the notion that gut microbiota plays a key role
in the regulation of various physiological and pathological processes related to human …

Metabolic Control During Macrophage Polarization by a Citrate‐Functionalized Scaffold for Maintaining Bone Homeostasis

X Wu, Y Xia, H Dai, C Hong, Y Zhao… - Advanced …, 2024 - Wiley Online Library
Metabolites, as markers of phenotype at the molecular level, can regulate the function of
DNA, RNA, and proteins through chemical modifications or interactions with large …

Recent Advances in Basic and Translational Osteoimmunology

RK Srivastava, K Schmidt-Bleek… - Frontiers in …, 2021 - frontiersin.org
CONCLUSION The field of “Osteoimmunology” will provide novel etiologic insights into
skeletal system-associated ailments in the near future. This might help in the design of …

Mitigating inflammatory bone loss in post-menopausal osteoporosis via targeting the IL-9 producing osteoclastogenic Th9 cells

L Sapra, C Saini, PK Mishra, N Chattopadhyay… - bioRxiv, 2023 - biorxiv.org
Recent discoveries have established the pivotal role of IL-9-secreting Th9 cells in a wide
spectrum of inflammatory and autoimmune diseases. However, little is known about how …

[HTML][HTML] Targeting “Immunoporosis” as a Novel Concept of Immunotherapy in the Management and Treatment of Osteoporosis

V Pol, T Kaur, A Bhardwaj, L Sapra… - Osteoporosis …, 2023 - intechopen.com
Osteoporosis is a skeleton disease characterized by low bone mass, bone tissue
deterioration, and alterations in bone microarchitecture. It is estimated that there are more …