Antimalarial and anticancer properties of artesunate and other artemisinins: current development

P Khanal - Monatshefte für Chemie-Chemical Monthly, 2021 - Springer
This review provides a recent perspective of artesunate and other artemisinins as
antimalarial drugs and their uses in cancer therapy. Artesunate is an artemisinin derivative …

Contribution of endophytes towards improving plant bioactive metabolites: a rescue option against red-taping of medicinal plants

S Tsipinana, S Husseiny, KA Alayande… - Frontiers in Plant …, 2023 - frontiersin.org
Medicinal plants remain a valuable source for natural drug bioprospecting owing to their
multi-target spectrum. However, their use as raw materials for novel drug synthesis has been …

[HTML][HTML] Nature-derived compounds modulating Wnt/β-catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases

G Sferrazza, M Corti, G Brusotti, P Pierimarchi… - … Pharmaceutica Sinica B, 2020 - Elsevier
The Wnt/β-catenin signaling is a conserved pathway that has a crucial role in embryonic and
adult life. Dysregulation of the Wnt/β-catenin pathway has been associated with diseases …

Transcriptome and Metabolome Reveal Salt-Stress Responses of Leaf Tissues from Dendrobium officinale

M Zhang, Z Yu, D Zeng, C Si, C Zhao, H Wang, C Li… - Biomolecules, 2021 - mdpi.com
Dendrobium officinale Kimura et Migo is a precious traditional Chinese medicine. Despite D.
officinale displaying a good salt-tolerance level, the yield and growth of D. officinale were …

Peroxides with anthelmintic, antiprotozoal, fungicidal and antiviral bioactivity: properties, synthesis and reactions

VA Vil', IA Yaremenko, AI Ilovaisky, AO Terent'ev - Molecules, 2017 - mdpi.com
The biological activity of organic peroxides is usually associated with the antimalarial
properties of artemisinin and its derivatives. However, the analysis of published data …

[HTML][HTML] AaMYB15, an R2R3-MYB TF in Artemisia annua, acts as a negative regulator of artemisinin biosynthesis

Z Wu, L Li, H Liu, X Yan, Y Ma, Y Li, T Chen, C Wang… - Plant Science, 2021 - Elsevier
Artemisinin is a secondary metabolite extracted from Artemisia annua. As an effective
antimalarial component certified by WHO, artemisinin has extensive economical values …

Transcriptomic analysis reveals the parallel transcriptional regulation of UV-B-induced artemisinin and flavonoid accumulation in Artemisia annua L.

Y Li, W Qin, X Fu, Y Zhang, D Hassani, SI Kayani… - Plant Physiology and …, 2021 - Elsevier
UV-B radiation is a pivotal photomorphogenic signal and positively regulates plant growth
and metabolite biosynthesis. In order to elucidate the transcriptional regulation mechanism …

[HTML][HTML] Stable production of the antimalarial drug artemisinin in the moss Physcomitrella patens

NKB Khairul Ikram, A Beyraghdar Kashkooli… - … in bioengineering and …, 2017 - frontiersin.org
Malaria is a real and constant danger to nearly half of the world's population of 7.4 billion
people. In 2015, 212 million cases were reported along with 429,000 estimated deaths. The …

Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives

DY Xie, DM Ma, R Judd, AL Jones - Phytochemistry reviews, 2016 - Springer
Artemisinin-based combination therapy (ACT) forms the frontline treatment of malaria.
Artemisinin, an endoperoxide sesquiterpenoid lactone biosynthesized by Artemisia annua …

[HTML][HTML] Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon

J de Alcantara Lemos, AEMFM Oliveira… - Biomedicine & …, 2021 - Elsevier
In the last few decades, utilization of medicinal plants by the pharmaceutical industry has led
to the identification of many new bioactive compounds. The genus Pterodon, native of the …