Acting in concert with individual susceptibility, environmental factors such as smoking, diet,
and pollutants play a role in most human cancer. However, new molecular evidence …

Breast cancer poses a serious public health problem, and it is hoped that identification of
genetic and environmental factors that contribute to the development of breast cancer will …

Purpose To characterise the prevalence of pathogenic germline mutations in BRCA1 and
BRCA2 in families with breast cancer (BC) and ovarian cancer (OC) history. Patients and …

Background Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk
for cancer have been estimated to have an 85 percent risk of breast cancer. Since the …

We have identified a novel protein, BAP1, which binds to the RING finger domain of the
Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized …

BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are found in most families with
cases of both breast and ovarian cancer or with many cases of early-onset breast cancer …

BACKGROUND The age‐specific proportion of breast and ovarian cancer in the general
population that is likely to be due to a breast/ovarian cancer susceptibility gene (s) is …

BRCA1 and BRCA2 are the two major identified causes of inherited breast cancer, with
mutations in either gene conferring up to 80–90% lifetime risk of breast cancer in carrier …

BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase
family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a …

Description: Update of the 2005 US Preventive Services Task Force (USPSTF)
recommendation on genetic risk assessment and BRCA mutation testing for breast and …