BACKGROUND Since it was established that the cognitive brain is formed mostly by an
interconnected network of neurons that communicate at contact sites termed synapses …

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

Far-field optical microscopy using focused light is an important tool in a number of scientific
disciplines including chemical,(bio) physical and biomedical research, particularly with …

The constant dynamic movement of synapses and their components has emerged in the last
decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein …

The brain is a dynamic structure with the extracellular space (ECS) taking up almost a
quarter of its volume,. Signalling molecules, neurotransmitters and nutrients transit via the …

Semiconductor quantum dots (QDs) are nanometer-sized fluorescent probes suitable for
advanced biological imaging. We used QDs to track individual glycine receptors (GlyRs) and …

The cellular processes that govern neuronal function are highly complex, with many basic
cell biological pathways uniquely adapted to perform the elaborate information processing …

Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …

Control of the glutamate time course in the synapse is crucial for excitatory transmission.
This process is mainly ensured by astrocytic transporters, high expression of which is …

Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism
for the plasticity of neuronal networks that is widely recognized to underlie cognitive …