The cyclopentenone unit is a very powerful synthon for the synthesis of a variety of bioactive
target molecules. This is due to the broad diversity of chemical modifications available for …

reductive elimination of the β-acyloxysulfone 4 with a single electron donor to afford alkene
products. All four steps can be carried out in a single reaction vessel, although in practice …

The molecular mechanisms through which oxidized lipids and their electrophilic
decomposition products mediate redox cell signalling is not well understood and may …

Since the beginning of the 1990's diverse types of metabolites originating from
polyunsaturated fatty acids, formed under autooxidative conditions were discovered. Known …

Polyunsaturated fatty acids (PUFAs) are important constituents in all organisms. They fulfil
many functions, ranging from modulating the structure of membranes to acting as precursors …

Isoprostanes (IsoPs), lipid peroxidation products formed via the free radical‐mediated
oxidation of arachidonic acid, have become the “gold standard” biomarker of oxidative stress …

A chemical study on the anti-inflammatory components of the red alga Gracilaria verrucosa
led to the isolation of new 11-deoxyprostaglandins (1–4), a ceramide (5), and a C16 keto …

We report a simple and highly stereocontrolled strategy toward the total synthesis of
isoprostanes based on a bicyclic α, β-epoxy ketone intermediate 6. Bicyclo [3.3. 0] octene …

Although both inflammation and oxidative stress contribute to the pathogenesis of many
disease states, the interaction between the two is poorly understood. Cyclopentenone …

Lipid peroxidation, a process known to induce oxidative damage to key cellular components,
has been implicated in several diseases. Following three decades of explorations mainly on …