Roles of microglia in brain development, tissue maintenance and repair
The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …
brain with a growing interest in their diverse functions. In recent years, it has been …
Non-coding RNAs as mediators of epigenetic changes in malignancies
S Kumar, EA Gonzalez, P Rameshwar, JP Etchegaray - Cancers, 2020 - mdpi.com
Simple Summary This review discusses the role of non-coding RNAs (ncRNAs) in cancer
epigenetics, mostly focusing on how deregulated microRNAs (miRNAs) and long non …
epigenetics, mostly focusing on how deregulated microRNAs (miRNAs) and long non …
MicroRNA-mediated control of macrophages and its implications for cancer
Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and
metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also …
metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also …
The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells
S Li, T Miao, M Sebastian, P Bhullar, E Ghaffari, M Liu… - Immunity, 2012 - cell.com
Lymphocytes provide optimal responses against pathogens with minimal inflammatory
pathology. However, the intrinsic mechanisms regulating these responses are unknown …
pathology. However, the intrinsic mechanisms regulating these responses are unknown …
The c-Myc-regulated microRNA-17∼ 92 (miR-17∼ 92) and miR-106a∼ 363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation
P Kumar, Y Luo, C Tudela, JM Alexander… - … and cellular biology, 2013 - Taylor & Francis
Mononuclear cytotrophoblasts of the human placenta proliferate rapidly, subsequently fuse,
and differentiate to form multinucleated syncytiotrophoblast with induction of aromatase …
and differentiate to form multinucleated syncytiotrophoblast with induction of aromatase …
miRNA–transcription factor interactions: a combinatorial regulation of gene expression
S Arora, R Rana, A Chhabra, A Jaiswal… - Molecular genetics and …, 2013 - Springer
Developmental processes require a precise spatio-temporal regulation of gene expression
wherein a diverse set of transcription factors control the signalling pathways. MicroRNAs …
wherein a diverse set of transcription factors control the signalling pathways. MicroRNAs …
mir‐17‐92: a polycistronic oncomir with pleiotropic functions
Neoplastic transformation is caused by accumulation of genetic lesions that ultimately
convert normal cells into tumor cells with uncontrolled proliferation and survival, unlimited …
convert normal cells into tumor cells with uncontrolled proliferation and survival, unlimited …
Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells
Background Compromised colonic butyrate production resulting from low dietary fiber or
altered gut microbiota may promote colon neoplasia. Previous reports indicate these actions …
altered gut microbiota may promote colon neoplasia. Previous reports indicate these actions …
Mechanisms of action of hematopoietic transcription factor PU. 1 in initiation of T-cell development
EV Rothenberg, H Hosokawa, J Ungerbäck - Frontiers in immunology, 2019 - frontiersin.org
PU. 1 is an ETS-family transcription factor that plays a broad range of roles in
hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs …
hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs …
MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused
to> 60 different partner genes. In order to define a core set of MLL rearranged targets, we …
to> 60 different partner genes. In order to define a core set of MLL rearranged targets, we …