One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …

Abstract Kleine–Levin Syndrome is a rare neurological disorder with onset typically during
adolescence that is characterized by recurrent episodes of hypersomnia, behavioral …

To assess the consistency of biological rhythms across studies, 57 public mouse liver tissue
timeseries totaling 1096 RNA-seq samples were obtained and analyzed. Only the control …

Background: Metabolic abnormalities have long been predicted in Huntington's disease
(HD) but remain poorly characterized. Chronobiological dysregulation has been described …

The striatum plays a central role in directing many complex behaviors ranging from motor
control to action choice and reward learning. In our study, we used 55 male CFW mice with …

The human striatum can be subdivided into the caudate, putamen, and nucleus accumbens
(NAc). In mice, this roughly corresponds to the dorsal medial striatum (DMS), dorsal lateral …

Sleep and circadian disruption affects most individuals with Huntington's disease (HD) at
some stage in their lives. Sleep and circadian dysregulation are also present in many mouse …

To provide rich functional context for HD gene set enrichment analysis, we developed an HD-
relevant gene set library called HDSigDB. The core of HDSigDB is derived from curation and …