Candida albicans, Candida auris, Candida glabrata, and Cryptococcus neoformans are
pathogenic yeasts which can cause systemic infections in immune-compromised as well as …

Aging is a leading cause of human morbidity and mortality, but efforts to slow or reverse its
effects are hampered by an incomplete understanding of its multi-faceted origins. Systems …

Lifespan is limited both by intrinsic decline in vigor with age and by accumulation of external
insults. There exists a general picture of the deficits of aging, one that is reflected in a pattern …

Application of microfluidic platforms facilitated high-precision measurements of yeast
replicative lifespan (RLS); however, comparative quantification of lifespan across strain …

Single-cell-level experimentation can elucidate key biological insights about cellular aging
that are masked in population-level studies. However, the extensive time requirement of …

Flux balance analysis (FBA) is a powerful tool to study genome-scale models of the cellular
metabolism, based on finding the optimal flux distributions over the network. While the …

Senescent cells play an important role in mammalian ageing and in the etiology of age-
related diseases. Treatment of mice with senolytics–drugs that selectively remove senescent …

As cells age, they undergo a remarkable global change: In transcriptional drift, hundreds of
genes become overexpressed while hundreds of others become underexpressed. Using …

For industrial processes, a fast, precise, and reliable method of determining the
physiological state of yeast cells, especially viability, is essential. However, an increasing …

Background Asymmetry during cellular division, both in the uneven partitioning of damaged
cellular components and of cell volume, is a cell biological phenomenon experienced by …