Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs
and permit greater control over their pharmacokinetics, biodistribution, and bioavailability …

For decades, nanomedicines have been reported as a potential means to overcome the
limitations of conventional drug delivery systems by reducing side effects, toxicity and the …

Biomacromolecules have long been at the leading edge of academic and pharmaceutical
drug development and clinical translation. With the clinical advances of new therapeutics …

CXC motif chemokine receptor 4 (CXCR4) is a promising therapeutic target of breast cancer
because it is overexpressed on cell surface of all molecular subtypes of breast cancer …

Introduction Subcutaneous physiology is distinct from other parenteral routes that benefit the
administration of prolonged-release formulations. A prolonged-release effect is particularly …

Surgery is a traditional tumor treatment, and immunotherapy can reduce the postoperative
recurrence of tumors. However, the intrinsic limits of low responsive rate and non‐tumor …

The acute inflammatory response is an inherent protective mechanism, and its unsuccessful
resolution can contribute to disease pathogenesis and potentially lead to death. Innate …

Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger
genetic elements, including" all-in-one" CRISPR/Cas9 plasmids, but is limited by toxicity as …

Two major obstacles that limit the widespread usage of polymeric nanocarriers include the
complexity of formulation methods and their stability during storage. To address both of …

In recent years, nanotechnology has grown significantly with enormous potential in
technology in research and medicine to improve tissue engineering, drug formulation and …